Impileo Lifescience pvt ltd

ASHBURN-DSR

Composition:  Rabeprazole 40mg, Domperidone 30mg SR

Rabeprazole: It is a proton pump inhibitor that inhibits gastric acid secretion and is taken orally in the form of its sodium salt.

Domperidone:- It is antiemetic medicine that increases the movements or contractions of stomach and bowel.

Mode of Action:-

Rabeprazole:- Rabeprazole belongs to a class of anti secretory compound that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid Secretion by inhibiting the gastric H + K + ATPase at the secretory surface of the gastric parietal.

Domperidone:- It is specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release and is used as antiemetic.

Indications and usage:-

Rabeprazole:

• It is used to treat excessive stomach pain
• Used in adults to promote healing of duodenal ulcers
• Use to treat symptoms of Gasteroesophageal reflux disease (GERD)

Domperidone:-

• It is used to prevent stomach problems such as nausea and vomiting associated with certain medications used to treat Parkinson’s disease
• It improves symptoms of nausea and vomiting, bloating, and feeling of fullness.

Side effects:-

Rabeprazole:-

• Nausea and vomiting
• Weight gain or loss
• Headache
• Yellow eyes
• Increased thirst
• Dark urine
• Cough

Domperidone:-

• Nausea
• Abdominal cramps
• Rash and itching
• Dry mouth
• Diarrhea